(Senior) Director, Clinical Pharmacology

Summary Lead the clinical pharmacology (CP) group of ~10 members, including clinical pharmacologists, pharmacometricians and toxicologists, to support global and/or regional development projects, ensuring all deliverables are based on science with high quality and timeliness. Responsibilities Provide CP expertise and guidance in clinical drug development programs of all therapeutic areas in study design (including dose rationales), data analyses to learn dose-exposure-response relationships and their variabilities, result interpretations and reporting Supervise and work with pharmacometricians in conducting PK (and/or PD) analysis (e.g., to integrate all regional data and investigate ethnic differences) for regulatory submissions in China Engage with management, regional and global (internal and external) stakeholders to drive CP strategies at project and portfolio levels Establish best practices for CP processes activities (e.g., modeling and simulation) to seek efficiency. Implement and explore process and data analysis strategies including AI/ML for science/innovation and for productivity Guide CP members in career development; coach and train junior members in applying quantitative methods and PK-PD knowledge to clinical projects Qualifications Ph.D./PharmD/MD in relevant disciplines (CP, pharmacokinetics [PK], , toxicokinetics, pharmacometrics) or other equivalent degrees or knowledge/expertise 8+ years of relevant clinical development experience in CP or Modeling & Simulation (M&S) roles Adequate people management experience with proven track records as a coach/trainer Excellent communication and negotiating skills with fluent in English (oral and written) Decent scientific publication records Skills In-depth understanding of CP, pharmacometrics, and their interfaces with (and good understanding of) DMPK, toxicology, biostatistics, clinical development, and regulatory science with quantitative, logical approach to drug development and common sensical business acumen. Ability to translate complex quantitative analyses into clear, actionable insights for cross‑functional and senior stakeholders. Strong scientific judgment, critical thinking, and decision‑making in ambiguous or data‑limited settings. Experience of working in global, matrix organizations with high scientific and regulatory standards. Effective management of stakeholders Date Posted 29-9月-2026 Closing Date 30-12月-2026 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.