Senior Medical Manager - Cell Therapy

Are you ready to lead the medical strategy that brings advanced cell therapies to patients across Brazil? Do you want to shape the launch of CAR-T in hematology and build the ecosystem that enables timely, safe, and sustainable patient access? Based in São Paulo/Cotia and reporting to the Medical Lead/Associate Medical Director – Hematology, you will own the end-to-end medical strategy for cell therapy, with a clear focus on launch readiness and real-world adoption. You will combine scientific leadership with operational excellence to design evidence plans, prepare treatment centers, and engage stakeholders who influence every step of the patient journey. This is a strategic role at the heart of Medical Affairs, where your work will translate cutting-edge science into clinical practice. You will collaborate cross-functionally to build the referral networks, education, and value demonstration required to make a lasting impact for patients, families and caregivers living with hematologic malignancies. Accountabilities: Medical Strategy and Launch Readiness Leadership: Lead the integrated medical strategy for cell therapy aligned with the brand plan; drive the Medical Launch Readiness framework; define priorities, KPIs and governance for pre-launch and launch phases; collaborate closely with SMM to ensure synchronized execution that accelerates adoption and patient impact. Scientific Leadership and Evidence Generation: Develop and lead evidence generation plans across RWE, registries, IIS and HEOR; build scientific credibility through publications and congress activities; lead KEE mapping, segmentation and engagement; organize advisory boards and consensus initiatives that inform practice and reduce barriers to care. Ecosystem Development (CAR-T Readiness): Build the national treatment ecosystem with Qualified Treatment Centers (QTCs) in partnership with the Cell Therapy Operational Specialist; assess infrastructure readiness (ICU, apheresis, logistics) and address gaps; design referral pathways and optimize patient flow; identify and mitigate operational and referral barriers to ensure timely treatment. Medical Education and Capability Building: Lead education for hematologists, transplant teams, pharmacists and nurses; develop specialized training on CRS/ICANS management and the CAR-T patient journey; ensure field medical readiness and scientific excellence that elevates standards of care. Access, Value and HEOR Strategy: Support value strategy through cost-effectiveness models and value dossier development; engage payers and institutional stakeholders; contribute to innovative access and reimbursement approaches that expand patient reach. Patient Readiness and Journey Optimization: Map and optimize the patient journey from identification to treatment and follow-up; support patient programs and educational materials; collaborate with patient advocacy organizations to enhance awareness and support. Regulatory, Compliance and Safety: Support ANVISA interactions and regulatory submissions; ensure pharmacovigilance readiness specific to cell therapy; uphold compliance with regulations and company policies; lead audit readiness to safeguard quality and trust. Cross-functional Leadership: Act as medical lead within cross-functional launch teams; collaborate with Market Access, Commercial, Regulatory and Supply to align plans and resolve constraints; participate in governance forums and launch planning that convert strategy into measurable outcomes. Stakeholder Engagement: Represent the company to key external experts, institutions and societies; build strategic partnerships with treatment centers and investigators that accelerate evidence generation and adoption. Essential Skills/Experience: - Degree in a healthcare-related field - Significant experience in Medical Affairs, preferably in hematology/oncology - Prior experience in launch or pre-launch environments - Prior experience in cell therapy, transplantation, or hematologic diseases (Mandatory) - Strong knowledge of clinical research, RWE and HEOR - Excellent communication and stakeholder engagement skills - Advanced English Desirable Skills/Experience: - Postgraduate degree - Experience in complex ecosystem building - Knowledge of Brazilian healthcare system - Strategic thinking, cross-functional leadership, stakeholder influence, execution excellence, people development Here, science and strategy come together to change how cancer is treated. You will work in an open, supportive environment where ambitious goals are matched by kindness and trust, and where bold ideas are welcome. Expect unexpected teams in the same room—clinicians, scientists, access experts and data specialists—unleashing thinking that turns evidence into better outcomes for patients and those who care for them. Your contribution will drive real-world impact across the patient journey, from diagnosis to long-term follow-up, and help move us closer to a future where fewer lives are lost to cancer. If you’re ready to lead Brazil’s cell therapy launch, build the ecosystem for CAR-T, and turn evidence into lives changed, take the next step and shape this impact with us. Date Posted 13-nov.-2026 Closing Date 22-nov.-2026 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.